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Molecular cloning of cDNA encoding Sm autoantigen: derivation of a cDNA for a B polypeptide of the U series of small nuclear ribonucleoprotein particles.

The Sm snRNPs play a central role in the processing of pre-mRNA. Anti-Sm antibodies, the diagnostic hallmark of systemic lupus erythematosus, target the B'/B and D polypeptides of these snRNPs. We have used patient autoantibodies to clone a cDNA from a human fibroblast cDNA library that encodes the...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Ohosone, Y, Mimori, T, Griffith, A, Akizuki, M, Homma, M, Craft, J, Hardin, J A
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1989
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC287428/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2524838/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.11.4249
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