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Proteinopathy-induced neuronal senescence: a hypothesis for brain failure in Alzheimer's and other neurodegenerative diseases

BACKGROUND: Alzheimer's disease (AD) and a host of other neurodegenerative central nervous system (CNS) proteinopathies are characterized by the accumulation of misfolded protein aggregates. Simplistically, these aggregates can be divided into smaller, soluble, oligomeric and larger, less-solub...

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Bibliografische gegevens
Hoofdauteurs: Golde, Todd E, Miller, Victor M
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2009
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2874257/
https://ncbi.nlm.nih.gov/pubmed/19822029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/alzrt5
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