Dicoumarol enhances gemcitabine-induced cytotoxicity in high NQO1-expressing cholangiocarcinoma cells

AIM: To investigate whether dicoumarol, a potent inhibitor of NAD(P)H quinone oxidoreductase-1 (NQO1), potentiates gemcitabine to induce cytotoxicity in cholangiocarcinoma cells (CCA) and the role of reactive oxygen generation in sensitizing the cells. METHODS: Four human cell lines with different N...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Buranrat, Benjaporn, Prawan, Auemduan, Kukongviriyapan, Upa, Kongpetch, Sarinya, Kukongviriyapan, Veerapol
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The WJG Press and Baishideng 2010
Aiheet:
Original Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2874140/
https://ncbi.nlm.nih.gov/pubmed/20480521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v16.i19.2362
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