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Single adduct mutagenesis: strong effect of the position of a single acetylaminofluorene adduct within a mutation hot spot.

2-Acetylaminofluorene (AAF), a potent rat liver carcinogen that binds covalently to the C-8 position of guanine residues in DNA, is an effective frameshift mutagen. The mutations are distributed nonrandomly, in that most are located at a few specific DNA sequences (i.e., mutation hot spots). Among t...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Burnouf, D, Koehl, P, Fuchs, R P
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1989
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC287406/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2657743/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.11.4147
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