Integrin-Blocking Antibodies Delay Keratinocyte Re-Epithelialization in a Human Three-Dimensional Wound Healing Model

The α6β4 integrin plays a significant role in tumor growth, angiogenesis and metastasis through modulation of growth factor signaling, and is a potentially important therapeutic target. However, α6β4-mediated cell-matrix adhesion is critical in normal keratinocyte attachment, signaling and anchorage...

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Bibliografiske detaljer
Main Authors: Egles, Christophe, Huet, Heather A., Dogan, Furkan, Cho, Sam, Dong, Shumin, Smith, Avi, Knight, Elana B., McLachlan, Karen R., Garlick, Jonathan A.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2873945/
https://ncbi.nlm.nih.gov/pubmed/20502640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010528
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