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Selection in spatial stochastic models of cancer: Migration as a key modulator of fitness

BACKGROUND: We study the selection dynamics in a heterogeneous spatial colony of cells. We use two spatial generalizations of the Moran process, which include cell divisions, death and migration. In the first model, migration is included explicitly as movement to a proximal location. In the second,...

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Библиографические подробности
Главные авторы: Thalhauser, Craig J, Lowengrub, John S, Stupack, Dwayne, Komarova, Natalia L
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2010
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2873940/
https://ncbi.nlm.nih.gov/pubmed/20406439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1745-6150-5-21
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