JAK2 Exon 12 Mutations in Polycythemia Vera and Idiopathic Erythrocytosis

BACKGROUND: The V617F mutation, which causes the substitution of phenylalanine for valine at position 617 of the Janus kinase (JAK) 2 gene (JAK2), is often present in patients with polycythemia vera, essential thrombocythemia, and idiopathic myelofibrosis. However, the molecular basis of these myelo...

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Detalhes bibliográficos
Main Authors: Scott, Linda M., Tong, Wei, Levine, Ross L., Scott, Mike A., Beer, Philip A., Stratton, Michael R., Futreal, P. Andrew, Erber, Wendy N., McMullin, Mary Frances, Harrison, Claire N., Warren, Alan J., Gilliland, D. Gary, Lodish, Harvey F., Green, Anthony R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2873834/
https://ncbi.nlm.nih.gov/pubmed/17267906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa065202
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