Chemical synthesis of echistatin, a potent inhibitor of platelet aggregation from Echis carinatus: synthesis and biological activity of selected analogs.

Echistatin, a polypeptide from the venom of the saw-scaled viper, Echis carinatus, containing 49 amino acids and 4 cystine bridges was synthesized by solid-phase methodology in 4% yield. In the final step, air oxidation of the octahydroderivative was found to be optimal at pH 8. The synthetic produc...

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Detalhes bibliográficos
Main Authors: Garsky, V M, Lumma, P K, Freidinger, R M, Pitzenberger, S M, Randall, W C, Veber, D F, Gould, R J, Friedman, P A
Formato: Artigo
Idioma:Inglês
Publicado em: 1989
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC287380/
https://ncbi.nlm.nih.gov/pubmed/2726764
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