Binding of actinomycin D to DNA: evidence for a nonclassical high-affinity binding mode that does not require GpC sites.

We have employed a combination of temperature-dependent UV absorption spectroscopy, circular dichroism, and batch calorimetry to characterize the binding of actinomycin D to a series of oligomeric DNA duplexes. We find the duplex [d(CGTCGACG)]2 to be unique in its ability to bind actinomycin D stron...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Snyder, J G, Hartman, N G, D'Estantoit, B L, Kennard, O, Remeta, D P, Breslauer, K J
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 1989
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC287369/
https://ncbi.nlm.nih.gov/pubmed/2726760
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