Different effects of the probe summarization algorithms PLIER and RMA on high-level analysis of Affymetrix exon arrays

BACKGROUND: Alternative splicing is an important mechanism that increases protein diversity and functionality in higher eukaryotes. Affymetrix exon arrays are a commercialized platform used to detect alternative splicing on a genome-wide scale. Two probe summarization algorithms, PLIER (Probe Logari...

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Main Authors: Qu, Yi, He, Fei, Chen, Yuchen
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2010
Teme:
Research article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2873539/
https://ncbi.nlm.nih.gov/pubmed/20426803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-11-211
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