Modulation of the virus-receptor interaction by mutations in the V5 loop of feline immunodeficiency virus (FIV) following in vivo escape from neutralising antibody

BACKGROUND: In the acute phase of infection with feline immunodeficiency virus (FIV), the virus targets activated CD4+ T cells by utilising CD134 (OX40) as a primary attachment receptor and CXCR4 as a co-receptor. The nature of the virus-receptor interaction varies between isolates; strains such as...

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Autori principali: Willett, Brian J, Kraase, Martin, Logan, Nicola, McMonagle, Elizabeth L, Samman, Ayman, Hosie, Margaret J
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2010
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2873508/
https://ncbi.nlm.nih.gov/pubmed/20420700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-7-38
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