Differentiating Embryonic Stem Cells Pass through ‘Temporal Windows’ That Mark Responsiveness to Exogenous and Paracrine Mesendoderm Inducing Signals

BACKGROUND: Mesendoderm induction during embryonic stem cell (ESC) differentiation in vitro is stimulated by the Transforming Growth Factor and Wingless (Wnt) families of growth factors. PRINCIPAL FINDINGS: We identified the periods during which Bone Morphogenetic Protein (BMP) 4, Wnt3a or Activin A...

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Autori principali: Jackson, Steven A., Schiesser, Jacqueline, Stanley, Edouard G., Elefanty, Andrew G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2010
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2873409/
https://ncbi.nlm.nih.gov/pubmed/20502661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010706
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