Functional Characterization of Vasopressin Type 2 Receptor Substitutions (R137H/C/L) Leading to Nephrogenic Diabetes Insipidus and Nephrogenic Syndrome of Inappropriate Antidiuresis: Implications for Treatments

Substitution of arginine-137 of the vasopressin type 2 receptor (V2R) for histidine (R137H-V2R) leads to nephrogenic diabetes insipidus (NDI), whereas substitution of the same residue to cysteine or leucine (R137C/L-V2R) causes the nephrogenic syndrome of inappropriate antidiuresis (NSIAD). These tw...

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Main Authors: Rochdi, Moulay D., Vargas, Gabriel A., Carpentier, Eric, Oligny-Longpré, Geneviève, Chen, Stanford, Kovoor, Abraham, Gitelman, Stephen E., Rosenthal, Stephen M., von Zastrow, Mark, Bouvier, Michel
Formato: Artigo
Idioma:Inglês
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2872969/
https://ncbi.nlm.nih.gov/pubmed/20159941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.109.061804
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