Regulators of G-protein Signaling accelerate GPCR signaling kinetics and govern sensitivity solely by accelerating GTPase activity

G-protein heterotrimers, composed of a guanine nucleotide-binding Gα subunit and an obligate Gβγ dimer, regulate signal transduction pathways by cycling between GDP- and GTP-bound states. Signal deactivation is achieved by Gα-mediated GTP hydrolysis (GTPase activity) which is enhanced by the GTPase-...

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Autors principals: Lambert, Nevin A., Johnston, Christopher A., Cappell, Steven D., Kuravi, Sudhakiranmayi, Kimple, Adam J., Willard, Francis S., Siderovski, David P.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2010
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2872438/
https://ncbi.nlm.nih.gov/pubmed/20351284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0912934107
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