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Protein Thermostability Calculations Using Alchemical Free Energy Simulations
Thermal stability of proteins is crucial for both biotechnological and therapeutic applications. Rational protein engineering therefore frequently aims at increasing thermal stability by introducing stabilizing mutations. The accurate prediction of the thermodynamic consequences caused by mutations,...
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| Autores principales: | , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
The Biophysical Society
2010
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2872215/ https://ncbi.nlm.nih.gov/pubmed/20483340 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.01.051 |
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