AFF4, a component of the ELL/p-TEFb elongation complex and a shared subunit of MLL chimeras can link transcription elongation to leukemia

Chromosomal translocations involving the MLL gene are associated with infant acute lymphoblastic and mixed lineage leukemia. There are a large number of translocation partners of MLL that share very little sequence or seemingly functional similarities, however, their translocations into MLL result i...

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Huvudupphovsmän: Lin, Chengqi, Smith, Edwin R., Takahashi, Hidehisa, Lai, Ka-Chun, Martin-Brown, Skylar, Florens, Laurence, Washburn, Michael P., Conaway, Joan W., Conaway, Ronald C., Shilatifard, Ali
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2872029/
https://ncbi.nlm.nih.gov/pubmed/20159561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.01.026
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