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A Combined Computational and Functional Approach Identifies New Residues Involved in pH-dependent Gating of ASIC1a
Acid-sensing ion channels (ASICs) are key receptors for extracellular protons. These neuronal nonvoltage-gated Na(+) channels are involved in learning, the expression of fear, neurodegeneration after ischemia, and pain sensation. We have applied a systematic approach to identify potential pH sensors...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2871499/ https://ncbi.nlm.nih.gov/pubmed/20299463 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.092015 |
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