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AKAR2-AKAP12 fusion protein "biosenses" dynamic phosphorylation and localization of a GPCR-based scaffold

BACKGROUND: The cAMP-dependent protein kinase A (PKA) plays a pivotal role in virtually all cells, there being a multitude of important target molecules that are substrates for PKA in cell signaling. The spatial-temporal dynamics of PKA activation in living cells has been made accessible by the deve...

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Библиографические подробности
Главные авторы: Tao, Jiangchuan, Wang, Hsien-yu, Malbon, Craig C
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2010
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2871262/
https://ncbi.nlm.nih.gov/pubmed/20412577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-2187-5-3
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