Autocrine, Not Paracrine, Interferon-Gamma Gene Delivery Enhances Ex Vivo Antigen-Specific Cytotoxic T Lymphocyte Stimulation and Killing

The adoptive transfer of antigen-specific cytotoxic T lymphocytes (CTL) shows promise in the treatment of cancer and infectious diseases. We utilize adeno-associated virus-(AAV-) based antigen gene-loaded dendritic cells (DCs) to stimulate such antigen-specific CTL. Yet further improvements in CTL s...

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Bibliographic Details
Main Authors: Zhang, Dazhi, Liu, Yong, Shi, Min, You, Chang Xuan, Cao, Maohua, Luo, Rong Cheng, Hermonat, Paul L.
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2871187/
https://ncbi.nlm.nih.gov/pubmed/20490265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2010/270985
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