Distamycin A Inhibits HMGA1-Binding to the P-Selectin Promoter and Attenuates Lung and Liver Inflammation during Murine Endotoxemia

BACKGROUND: The architectural transcription factor High Mobility Group-A1 (HMGA1) binds to the minor groove of AT-rich DNA and forms transcription factor complexes (“enhanceosomes”) that upregulate expression of select genes within the inflammatory cascade during critical illness syndromes such as a...

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Main Authors: Baron, Rebecca M., Lopez-Guzman, Silvia, Riascos, Dario F., Macias, Alvaro A., Layne, Matthew D., Cheng, Guiying, Harris, Cailin, Chung, Su Wol, Reeves, Raymond, von Andrian, Ulrich H., Perrella, Mark A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2871042/
https://ncbi.nlm.nih.gov/pubmed/20498830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010656
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