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Activation of Sterol Regulatory Element Binding Proteins in the Absence of Scap in Drosophila melanogaster

The escort factor Scap is essential in mammalian cells for regulated activation of sterol regulatory element binding proteins (SREBPs). SREBPs are membrane-bound transcription factors. Cells lacking Scap cannot activate SREBP. They are therefore deficient in the transcription of numerous genes invol...

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Detalhes bibliográficos
Main Authors: Matthews, Krista A., Ozdemir, Cafer, Rawson, Robert B.
Formato: Artigo
Idioma:Inglês
Publicado em: Genetics Society of America 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2870954/
https://ncbi.nlm.nih.gov/pubmed/20176975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.110.114975
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