Null mutation of copper/zinc superoxide dismutase in Drosophila confers hypersensitivity to paraquat and reduced longevity.

The role of copper/zinc-containing superoxide dismutase (cSOD; superoxide:superoxide oxidoreductase, EC 1.15.1.1) in metabolic defense against O2 toxicity in Drosophila is examined through the properties of a mutant strain carrying a cSOD-null mutation, cSODn108. Homozygotes are viable as larvae, wh...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Phillips, J P, Campbell, S D, Michaud, D, Charbonneau, M, Hilliker, A J
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1989
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC286998/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2539600/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.8.2761
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