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Null mutation of copper/zinc superoxide dismutase in Drosophila confers hypersensitivity to paraquat and reduced longevity.

The role of copper/zinc-containing superoxide dismutase (cSOD; superoxide:superoxide oxidoreductase, EC 1.15.1.1) in metabolic defense against O2 toxicity in Drosophila is examined through the properties of a mutant strain carrying a cSOD-null mutation, cSODn108. Homozygotes are viable as larvae, wh...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Phillips, J P, Campbell, S D, Michaud, D, Charbonneau, M, Hilliker, A J
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1989
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC286998/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2539600/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.8.2761
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