A Forward Genetic Screen in Mice Identifies Sema3A(K108N), which Binds to Neuropilin-1 but Cannot Signal

We have performed a three-generation, forward genetic screen to identify recessive mutations that affect the patterning of the peripheral nervous system. Using this assay, we identified Sema3A(K108N), a novel loss-of-function allele of Sema3A. Class 3 semaphorins, which include Sema3A, are structura...

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Detalhes bibliográficos
Main Authors: Merte, Janna, Wang, Qiang, Vander Kooi, Craig W., Sarsfield, Sarah, Leahy, Daniel J., Kolodkin, Alex L., Ginty, David D.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2869466/
https://ncbi.nlm.nih.gov/pubmed/20410128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5061-09.2010
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