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Inside-Out Regulation of L1 Conformation, Integrin Binding, Proteolysis, and Concomitant Cell Migration

Previous reports on the expression of the cell adhesion molecule L1 in pancreatic ductal adenocarcinoma (PDAC) cells range from absent to high. Our data demonstrate that L1 is expressed in poorly differentiated PDAC cells in situ and that threonine-1172 (T1172) in the L1 cytoplasmic domain exhibits...

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Detalhes bibliográficos
Main Authors: Chen, Maxine M., Lee, Chia-Yao, Leland, Hyuma A., Lin, Grace Y., Montgomery, Anthony M., Silletti, Steve
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2869374/
https://ncbi.nlm.nih.gov/pubmed/20335502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E09-10-0900
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