Loss of GluN2B-Containing NMDA Receptors in CA1 Hippocampus and Cortex Impairs Long-Term Depression, Reduces Dendritic Spine Density, and Disrupts Learning

NMDA receptors (NMDARs) are key mediators of certain forms of synaptic plasticity and learning. NMDAR complexes are heteromers composed of an obligatory GluN1 subunit and one or more GluN2 (GluN2A–GluN2D) subunits. Different subunits confer distinct physiological and molecular properties to NMDARs,...

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Main Authors: Brigman, Jonathan L., Wright, Tara, Talani, Giuseppe, Prasad-Mulcare, Shweta, Jinde, Seiichiro, Seabold, Gail K., Mathur, Poonam, Davis, Margaret I., Bock, Roland, Gustin, Richard M., Colbran, Roger J., Alvarez, Veronica A., Nakazawa, Kazu, Delpire, Eric, Lovinger, David M., Holmes, Andrew
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2869199/
https://ncbi.nlm.nih.gov/pubmed/20357110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0640-10.2010
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