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Creation of a novel telomere-cutting endonuclease based on the EN domain of telomere-specific non-long terminal repeat retrotransposon, TRAS1

BACKGROUND: The ends of chromosomes, termed telomeres consist of repetitive DNA. The telomeric sequences shorten with cell division and, when telomeres are critically abbreviated, cells stop proliferating. However, in cancer cells, by the expression of telomerase which elongates telomeres, the cells...

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Bibliografiske detaljer
Main Authors: Yoshitake, Kazutoshi, Aoyagi, Hideyuki, Fujiwara, Haruhiko
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2868851/
https://ncbi.nlm.nih.gov/pubmed/20359340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1759-8753-1-13
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