Enhanced synaptic connectivity and epilepsy in C1q knockout mice

Excessive CNS synapses are eliminated during development to establish mature patterns of neuronal connectivity. A complement cascade protein, C1q, is involved in this process. Mice deficient in C1q fail to refine retinogeniculate connections resulting in excessive retinal innervation of lateral geni...

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Detalles Bibliográficos
Autores principales: Chu, Yunxiang, Jin, Xiaoming, Parada, Isabel, Pesic, Alexei, Stevens, Beth, Barres, Ben, Prince, David A.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2010
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867906/
https://ncbi.nlm.nih.gov/pubmed/20375278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0913449107
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