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Enhanced synaptic connectivity and epilepsy in C1q knockout mice
Excessive CNS synapses are eliminated during development to establish mature patterns of neuronal connectivity. A complement cascade protein, C1q, is involved in this process. Mice deficient in C1q fail to refine retinogeniculate connections resulting in excessive retinal innervation of lateral geni...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2867906/ https://ncbi.nlm.nih.gov/pubmed/20375278 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0913449107 |
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