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Genetic variants near TIMP3 and high-density lipoprotein–associated loci influence susceptibility to age-related macular degeneration

We executed a genome-wide association scan for age-related macular degeneration (AMD) in 2,157 cases and 1,150 controls. Our results validate AMD susceptibility loci near CFH (P < 10(−75)), ARMS2 (P < 10(−59)), C2/CFB (P < 10(−20)), C3 (P < 10(−9)), and CFI (P < 10(−6)). We compared o...

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Päätekijät: Chen, Wei, Stambolian, Dwight, Edwards, Albert O., Branham, Kari E., Othman, Mohammad, Jakobsdottir, Johanna, Tosakulwong, Nirubol, Pericak-Vance, Margaret A., Campochiaro, Peter A., Klein, Michael L., Tan, Perciliz L., Conley, Yvette P., Kanda, Atsuhiro, Kopplin, Laura, Li, Yanming, Augustaitis, Katherine J., Karoukis, Athanasios J., Scott, William K., Agarwal, Anita, Kovach, Jaclyn L., Schwartz, Stephen G., Postel, Eric A., Brooks, Matthew, Baratz, Keith H., Brown, William L., Brucker, Alexander J., Orlin, Anton, Brown, Gary, Ho, Allen, Regillo, Carl, Donoso, Larry, Tian, Lifeng, Kaderli, Brian, Hadley, Dexter, Hagstrom, Stephanie A., Peachey, Neal S., Klein, Ronald, Klein, Barbara E. K., Gotoh, Norimoto, Yamashiro, Kenji, Ferris, Frederick, Fagerness, Jesen A., Reynolds, Robyn, Farrer, Lindsay A., Kim, Ivana K., Miller, Joan W., Cortón, Marta, Carracedo, Angel, Sanchez-Salorio, Manuel, Pugh, Elizabeth W., Doheny, Kimberly F., Brion, Maria, DeAngelis, Margaret M., Weeks, Daniel E., Zack, Donald J., Chew, Emily Y., Heckenlively, John R., Yoshimura, Nagahisa, Iyengar, Sudha K., Francis, Peter J., Katsanis, Nicholas, Seddon, Johanna M., Haines, Jonathan L., Gorin, Michael B., Abecasis, Gonçalo R., Swaroop, Anand, Johnson, Robert N., Ai, Everett, McDonald, H. Richard, Stolarczuk, Margaret, Pavan, Peter Reed, Billiris, Karina K., Iyer, Mohan, Menosky, Matthew M., Pautler, Scott E., Millard, Sharon M., Hubbard, Baker, Aaberg, Thomas, DuBois, Lindy, Lyon, Alice, Anderson-Nelson, Susan, Jampol, Lee M., Weinberg, David V., Muñana, Annie, Rozenbajgier, Zuzanna, Orth, David, Cohen, Jack, MacCumber, Matthew, Figliulo, Celeste, Porcz, Liz, Folk, James, Boldt, H. Culver, Russell, Stephen R., Ivins, Rachel, Hinz, Connie J., Barr, Charles C., Bloom, Steve, Jaegers, Ken, Kritchman, Brian, Whittington, Greg, Heier, Jeffrey, Frederick, Albert R., Morley, Michael G., Topping, Trexler, Davis, Heather L., Bressler, Susan B., Bressler, Neil M., Doll, Warren, Trese, Michael, Capone, Antonio, Garretson, Bruce R., Hassan, Tarek S., Ruby, Alan J., Osentoski, Tammy, McCannel, Colin A., Ruszczyk, Margaret J., Grand, Gilbert, Blinder, Kevin, Holekamp, Nancy M., Joseph, Daniel P., Shah, Gaurav, Nobel, Ginny S., Antoszyk, Andrew N., Browning, David J., Stallings, Alison H, Singerman, Lawrence J., Miller, David, Novak, Michael, Pendergast, Scott, Zegarra, Hernando, Schura, Stephanie A., Smith-Brewer, Sheila, Davidorf, Frederick H., Chambers, Robert, Chorich, Louis, Salerno, Jill, Dreyer, Richard F., Ma, Colin, Kopfer, Marcia R., Wilson, David J., Nolte, Susan K., Grunwald, Juan E., Dunaief, Josh, Fine, Stuart L., Maguire, Albert M., Stoltz, Robert A., McRay, Monique N., Fish, Gary Edd, Anand, Rajiv, Spencer, Rand, Arnwine, Jean, Chandra, Suresh R., Altaweel, Michael, Blodi, Barbara, Gottlieb, Justin, Ip, Michael, Nork, T. Michael, Perry-Raymond, Jennie, Maguire, Maureen G., Brightwell-Arnold, Mary, Harkins, Sandra, Peskin, Ellen, Ying, Gui-Shuang, Kurinij, Natalie
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2010
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Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867722/
https://ncbi.nlm.nih.gov/pubmed/20385819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0912702107
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