Recapitulation of endochondral bone formation using human adult mesenchymal stem cells as a paradigm for developmental engineering

Mesenchymal stem/stromal cells (MSC) are typically used to generate bone tissue by a process resembling intramembranous ossification, i.e., by direct osteoblastic differentiation. However, most bones develop by endochondral ossification, i.e., via remodeling of hypertrophic cartilaginous templates....

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Main Authors: Scotti, Celeste, Tonnarelli, Beatrice, Papadimitropoulos, Adam, Scherberich, Arnaud, Schaeren, Stefan, Schauerte, Alexandra, Lopez-Rios, Javier, Zeller, Rolf, Barbero, Andrea, Martin, Ivan
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2010
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867676/
https://ncbi.nlm.nih.gov/pubmed/20406908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1000302107
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