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Pentosan polysulfate treatment preserves renal autoregulation in ANG II-infused hypertensive rats via normalization of P2X(1) receptor activation

Inflammatory factors are elevated in animal and human subjects with hypertension and renal injury. We hypothesized that inflammation contributes to hypertension-induced renal injury by impairing autoregulation and microvascular reactivity to P2X(1) receptor activation. Studies were conducted in vitr...

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Autores principales: Guan, Zhengrong, Fuller, Barry S., Yamamoto, Tatsuo, Cook, Anthony K., Pollock, Jennifer S., Inscho, Edward W.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2010
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867410/
https://ncbi.nlm.nih.gov/pubmed/20200092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00743.2009
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