Induced ATF-2 represses CDK4 transcription through dimerization with JunD inhibiting intestinal epithelial cell growth after polyamine depletion

Intestinal epithelium is a rapidly self-renewing tissue in the body, and its homeostasis is tightly regulated by numerous factors including polyamines. Decreased levels of cellular polyamines increase activating transcription factor (ATF)-2, but the exact role and mechanism of induced ATF-2 in the r...

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Main Authors: Xiao, Lan, Rao, Jaladanki N., Zou, Tongtong, Liu, Lan, Yu, Ting-Xi, Zhu, Xiao-Yu, Donahue, James M., Wang, Jian-Ying
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2010
Assuntos:
Growth, Differentiation, and Apoptosis
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867388/
https://ncbi.nlm.nih.gov/pubmed/20181929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00021.2010
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