The Apc(min) mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS

Apc, a negative regulator of the canonical Wnt signaling pathway, is a bona-fide tumor suppressor whose loss of function results in intestinal polyposis. APC is located in a commonly deleted region on human chromosome 5q, associated with myelodysplastic syndrome (MDS), suggesting that haploinsuffici...

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Main Authors: Lane, Steven W., Sykes, Stephen M., Al-Shahrour, Fatima, Shterental, Sebastian, Paktinat, Mahnaz, Lo Celso, Cristina, Jesneck, Jonathan L., Ebert, Benjamin L., Williams, David A., Gilliland, D. Gary
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2010
Teme:
Hematopoiesis and Stem Cells
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867262/
https://ncbi.nlm.nih.gov/pubmed/20197553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-11-251728
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