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Conformational changes in oxidatively stressed monoclonal antibodies studied by hydrogen exchange mass spectrometry
Oxidation of methionine residues in biopharmaceuticals is a common and often unwanted modification that frequently occurs during their manufacture and storage. It often results in a lack of stability and biological function of the product, necessitating continuous testing for the modification throug...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Wiley Subscription Services, Inc., A Wiley Company
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2867022/ https://ncbi.nlm.nih.gov/pubmed/20162626 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.362 |
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