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Critical biophysical properties in the Pseudomonas aeruginosa efflux gene regulator MexR are targeted by mutations conferring multidrug resistance

The self-assembling MexA-MexB-OprM efflux pump system, encoded by the mexO operon, contributes to facile resistance of Pseudomonas aeruginosa by actively extruding multiple antimicrobials. MexR negatively regulates the mexO operon, comprising two adjacent MexR binding sites, and is as such highly ta...

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Hlavní autoři: Andrésen, Cecilia, Jalal, Shah, Aili, Daniel, Wang, Yi, Islam, Sohidul, Jarl, Anngelica, Liedberg, Bo, Wretlind, Bengt, Mårtensson, Lars-Göran, Sunnerhagen, Maria
Médium: Artigo
Jazyk:Inglês
Vydáno: Wiley Subscription Services, Inc., A Wiley Company 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867009/
https://ncbi.nlm.nih.gov/pubmed/20095047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.343
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