Mutants of human colon adenocarcinoma, selected for thymidylate synthase deficiency.
GC3/c1 human colon adenocarcinoma cells were treated with the mutagen ethyl methanesulfonate, and three clones deficient in thymidylate synthase (5,10-methylenetetrahydrofolate:dUMP C-methyltransferase, EC 2.1.1. 45) activity were selected and characterized. Growth in medium deficient in thymidine c...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
1989
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC286693/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2537495/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.4.1377 |
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