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Reversibly bound chloride in the atrial natriuretic peptide receptor hormone-binding domain: Possible allosteric regulation and a conserved structural motif for the chloride-binding site

The binding of atrial natriuretic peptide (ANP) to its receptor requires chloride, and it is chloride concentration dependent. The extracellular domain (ECD) of the ANP receptor (ANPR) contains a chloride near the ANP-binding site, suggesting a possible regulatory role. The bound chloride, however,...

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Bibliografische gegevens
Hoofdauteurs: Ogawa, Haruo, Qiu, Yue, Philo, John S, Arakawa, Tsutomu, Ogata, Craig M, Misono, Kunio S
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Wiley Subscription Services, Inc., A Wiley Company 2010
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2866279/
https://ncbi.nlm.nih.gov/pubmed/20066666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.332
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