A Pharmacokinetic and Pharmacodynamic Study of Delayed- and Extended-Release Hydrocortisone (Chronocort™) versus Conventional Hydrocortisone (Cortef™) in the Treatment of Congenital Adrenal Hyperplasia

SUMMARY: OBJECTIVE: Existing glucocorticoid treatment for congenital adrenal hyperplasia (CAH) is suboptimal and nonphysiological. We compared hormonal profiles during therapy with a new modified-release hydrocortisone (MR-HC), Chronocort™, to conventional hydrocortisone (HC), Cortef™, in patients w...

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Main Authors: Verma, Somya, VanRyzin, Carol, Sinaii, Ninet, Kim, Mimi S., Nieman, Lynnette K., Ravindran, Shayna, Calis, Karim A., Arlt, Wiebke, Ross, Richard J., Merke, Deborah P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2866132/
https://ncbi.nlm.nih.gov/pubmed/19486026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2265.2009.03636.x
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