Expression of a G Protein-coupled Receptor (GPCR) Leads to Attenuation of Signaling by Other GPCRs: EXPERIMENTAL EVIDENCE FOR A SPONTANEOUS GPCR CONSTITUTIVE INACTIVE FORM

The idea of G protein-coupled receptors (GPCRs) coupling to G protein solely in their active form was abolished when it was found that certain ligands induce a G protein-coupled but inactive receptor form. This receptor form interferes with signaling of other receptors by sequestering G protein. How...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Tubio, Maria Rosario, Fernandez, Natalia, Fitzsimons, Carlos Patricio, Copsel, Sabrina, Santiago, Sergio, Shayo, Carina, Davio, Carlos, Monczor, Federico
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society for Biochemistry and Molecular Biology 2010
الموضوعات:
Signal Transduction
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865266/
https://ncbi.nlm.nih.gov/pubmed/20299453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.099689
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