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Understanding loss of donor white blood cell immunogenicity following pathogen reduction: mechanisms of action in UV illumination and riboflavin treatment

BACKGROUND: Donor white blood cells (WBCs) present in transfusion products can lead to immune sequelae such as production of anti-HLA antibodies or GVHD in susceptible transfusion recipients. Eliminating the immunogenicity of blood products may prove to be of clinical benefit, particularly in patien...

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Detalhes bibliográficos
Main Authors: Jackman, Rachael P., Heitman, John W., Marschner, Susanne, Goodrich, Raymond P., Norris, Philip J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865145/
https://ncbi.nlm.nih.gov/pubmed/19682337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1537-2995.2009.02333.x
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