Defective cAMP Generation Underlies the Sensitivity of CNS Neurons to Neurofibromatosis-1 Heterozygosity

Individuals with the neurofibromatosis type 1 (NF1) inherited cancer syndrome exhibit neuronal dysfunction that predominantly affects the CNS. In this report, we demonstrate a unique vulnerability of CNS neurons, but not peripheral nervous system (PNS) neurons, to reduced Nf1 gene expression. Unlike...

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Main Authors: Brown, Jacquelyn A., Gianino, Scott M., Gutmann, David H.
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2010
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2864934/
https://ncbi.nlm.nih.gov/pubmed/20410111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3994-09.2010
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