Contributions of the Histidine Side Chain and the N-terminal α-Amino Group to the Binding Thermodynamics of Oligopeptides to Nucleic Acids as a Function of pH

Interactions of histidine with nucleic acid phosphates and histidine pK(a) shifts make important contributions to many protein-nucleic acid binding processes. To characterize these phenomena in simplified systems, we quantified binding of a histidine-containing model peptide HWKK ((+)NH(3)-His-Trp-L...

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Detalhes bibliográficos
Main Authors: Ballin, Jeff D., Prevas, James P., Ross, Christina R., Toth, Eric A., Wilson, Gerald M., Record, M. Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2864607/
https://ncbi.nlm.nih.gov/pubmed/20108951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi902027z
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