Prime-Boost Vaccination Using Chemokine-Fused gp120 DNA and HIV Envelope Peptides Activates Both Immediate and Long-Term Memory Cellular Responses in Rhesus Macaques

HIV vaccine candidates with improved immunogenicity and induction of mucosal T-cell immunity are needed. A prime-boost strategy using a novel HIV glycoprotein 120 DNA vaccine was employed to immunize rhesus macaques. The DNA vaccine encoded a chimeric gp120 protein in fusion with monocyte chemoattra...

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Detalhes bibliográficos
Main Authors: Qin, Hong, Nehete, Pramod N., He, Hong, Nehete, Bharti, Buchl, Stephanie, Cha, Soung-chul, Sastry, Jagannadha K., Kwak, Larry W.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2864514/
https://ncbi.nlm.nih.gov/pubmed/20454526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2010/860160
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