GSK3β and β-Catenin Modulate Radiation Cytotoxicity in Pancreatic Cancer

BACKGROUND: Knowledge of factors and mechanisms contributing to the inherent radioresistance of pancreatic cancer may improve cancer treatment. Irradiation inhibits glycogen synthase kinase 3β (GSK3β) by phosphorylation at serine 9. In turn, release of cytosolic membrane β-catenin with subsequent nu...

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Detalhes bibliográficos
Main Authors: Watson, Richard L, Spalding, Aaron C, Zielske, Steven P, Morgan, Meredith, Kim, Alex C, Bommer, Guido T, Eldar-Finkelman, Hagit, Giordano, Thomas, Fearon, Eric R, Hammer, Gary D, Lawrence, Theodore S, Ben-Josef, Edgar
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press Inc. 2010
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2864473/
https://ncbi.nlm.nih.gov/pubmed/20454507
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