Positive genetic selection for gene disruption in mammalian cells by homologous recombination.
Efficient modification of genes in mammalian cells by homologous recombination has not been possible because of the high frequency of nonhomologous recombination. An efficient method for targeted gene disruption has been developed. Cells with substitution of exogenous sequences into a chromosomal lo...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
1989
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC286437/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2536156/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.1.227 |
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