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Pharmacogenomic Variation of CYP2D6 and the Choice of Optimal Adjuvant Endocrine Therapy for Postmenopausal Breast Cancer: A Modeling Analysis

BACKGROUND: Adjuvant endocrine treatment with aromatase inhibitors improves disease-free survival compared with tamoxifen in postmenopausal women with estrogen receptor–positive breast cancer. This difference could be due to differences in tamoxifen metabolism because levels of endoxifen, the active...

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Detalhes bibliográficos
Main Authors: Punglia, Rinaa S., Burstein, Harold J., Winer, Eric P., Weeks, Jane C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2864146/
https://ncbi.nlm.nih.gov/pubmed/18445827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djn100
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