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Fungal Homoserine Kinase (thr1Δ) Mutants Are Attenuated in Virulence and Die Rapidly upon Threonine Starvation and Serum Incubation

The fungally conserved subset of amino acid biosynthetic enzymes not present in humans offer exciting potential as an unexploited class of antifungal drug targets. Since threonine biosynthesis is essential in Cryptococcus neoformans, we further explored the potential of threonine biosynthetic enzyme...

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Détails bibliographiques
Auteurs principaux: Kingsbury, Joanne M., McCusker, John H.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863962/
https://ncbi.nlm.nih.gov/pubmed/20305003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/EC.00045-10
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