Identification of a Dominant Negative Inhibitor of Human Zinc Finger Antiviral Protein Reveals a Functional Endogenous Pool and Critical Homotypic Interactions

The zinc finger antiviral protein (ZAP) is a host factor with potent antiviral activity when overexpressed in cells. ZAP blocks replication of the prototype alphavirus Sindbis virus (SINV) at a step at or before translation of the incoming viral genome. The mechanism of ZAP anti-SINV activity and th...

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Detalhes bibliográficos
Main Authors: Law, Lok Man J., Albin, Owen R., Carroll, John-William N., Jones, Christopher T., Rice, Charles M., MacDonald, Margaret R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Cellular Response to Infection
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863759/
https://ncbi.nlm.nih.gov/pubmed/20181706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02018-09
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