SDF-1/CXCL12 Production by Mature Dendritic Cells Inhibits the Propagation of X4-Tropic HIV-1 Isolates at the Dendritic Cell-T-Cell Infectious Synapse

An efficient mode of HIV-1 infection of CD4 lymphocytes occurs in the context of infectious synapses, where dendritic cells (DCs) enhance HIV-1 transmission to lymphocytes. Emergence of CXCR4-using (X4) HIV-1 strains occurs late in the course of HIV-1 infection, suggesting that a selective pressure...

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Autori principali: González, Nuria, Bermejo, Mercedes, Calonge, Esther, Jolly, Clare, Arenzana-Seisdedos, Fernando, Pablos, José L., Sattentau, Quentin J., Alcamí, José
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2010
Soggetti:
Pathogenesis and Immunity
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863755/
https://ncbi.nlm.nih.gov/pubmed/20181695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02449-09
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