In Vitro and In Vivo Activities of 1,3,4-Thiadiazole-2-Arylhydrazone Derivatives of Megazol against Trypanosoma cruzi

From a series of 1,3,4-thiadiazole-2-arylhydrazone derivatives of megazol screened in vitro against Trypanosoma cruzi, eight (S1 to S8) were selected for in vivo screening by single-dose oral administration (200 mg/kg of body weight) to infected mice at 5 days postinfection (dpi). Based on significa...

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Hlavní autoři: Salomão, K., de Souza, E. M., Carvalho, S. A., da Silva, E. F., Fraga, C. A. M., Barbosa, H. S., de Castro, S. L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2010
Témata:
Susceptibility
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863677/
https://ncbi.nlm.nih.gov/pubmed/20231395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01241-09
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