Detection of E119V and E119I Mutations in Influenza A (H3N2) Viruses Isolated from an Immunocompromised Patient: Challenges in Diagnosis of Oseltamivir Resistance

The clinical use of the neuraminidase inhibitor (NAI) oseltamivir is associated with the emergence of drug resistance resulting from subtype-specific neuraminidase (NA) mutations. The influenza A/Texas/12/2007 (H3N2) virus isolated from an oseltamivir-treated immunocompromised patient exhibited redu...

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Bibliographic Details
Main Authors: Okomo-Adhiambo, Margaret, Demmler-Harrison, Gail J., Deyde, Varough M., Sheu, Tiffany G., Xu, Xiyan, Klimov, Alexander I., Gubareva, Larisa V.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2010
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863645/
https://ncbi.nlm.nih.gov/pubmed/20194700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01608-09
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